Skudexa 75mg/25mg Film-Coated Tablets 15s (Box)

Skudexa 75mg/25mg Film-Coated Tablets is a combination prescription medicine belonging to the NSAID (non-steroidal anti-inflammatory drug) class, containing two active ingredients — dexketoprofen and tramadol hydrochloride — working together in a single tablet. If you're wondering what to expect from this medicine, it's worth knowing that like most medications in this category, it may cause some side effects such as nausea, dizziness, vomiting, and drowsiness in some people.

This is a prescription-only medicine, which means your doctor or healthcare provider will assess whether it is right for you before recommending it. You should always let your doctor know about any other medicines you are currently taking or any health conditions you have, as this helps ensure your safety throughout your treatment in Singapore.

The generally recommended dose for adults is one tablet taken up to a maximum of three times daily, with each dose spaced at least 8 hours apart, and the total daily intake should not exceed three tablets (225mg tramadol / 75mg dexketoprofen) in a 24-hour period. Always follow your doctor's prescribed dosage instructions, as individual requirements may vary depending on your medical condition, age, and kidney or liver function.

Common Side Effects

• Nausea
• Dizziness
• Vomiting
• Drowsiness (somnolence)
• Headache
• Constipation
• Dry mouth (xerostomia)
• Stomach discomfort, indigestion, or diarrhoea
• Fatigue or tiredness
• Sweating

Serious Side Effects (Seek Immediate Medical Attention)

• Severe allergic reactions (anaphylaxis), including swelling of the face, lips, tongue, or throat
• Difficulty breathing or shortness of breath
• Gastrointestinal bleeding or ulceration
• Seizures (convulsions)
• Hallucinations or confusion
• Severe skin reactions (e.g., Stevens-Johnson syndrome)
• Serotonin syndrome (especially when taken with other serotonergic medicines)

• Store below 30°C in a cool, dry place away from direct sunlight and moisture.
• Keep the tablets in their original blister packaging until you are ready to use them.
• Do not store in the bathroom, near a sink, or in any area with high humidity.
• Keep this medicine out of the reach and sight of children at all times.
• If you are unsure whether your medicine has been stored correctly, consult your Singapore pharmacist before taking it.

• Always take Skudexa exactly as prescribed by your doctor. Do not adjust your dose or stop treatment without medical advice.
• Take the tablet with food or after a meal to help reduce the risk of stomach upset or irritation.
• Swallow the film-coated tablet whole with a full glass of water. Do not crush, split, or chew it.
• Avoid alcohol while taking this medicine, as it may increase the risk of serious side effects.
• Do not drive or operate heavy machinery until you know how Skudexa affects you, as it may cause dizziness or drowsiness.
• Tell your doctor or pharmacist about all medicines, supplements, or herbal products you are taking before starting Skudexa.
• If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue as usual. Do not take a double dose.
• Seek immediate medical attention if you develop signs of a serious allergic reaction, difficulty breathing, or other severe symptoms after taking this medicine.

Skudexa 75mg/25mg Film-Coated Tablets should be taken orally, swallowed whole with a sufficient amount of water — do not crush, chew, or break the tablet. It is generally recommended to take this medicine with food or shortly after eating to help reduce the chance of stomach discomfort, and you should always follow the specific instructions given by your prescribing doctor or pharmacist in Singapore. Never take more than the prescribed dose or use it for longer than directed by your healthcare professional.

Skudexa 75mg/25mg Film-Coated Tablets typically has a shelf life of 3 years from the date of manufacture when stored under the recommended conditions. Always check the expiry date printed on the outer carton and blister pack before use, and never take the tablets if the expiry date has passed. Expired medicines should be disposed of safely and responsibly — do not flush them down the toilet or throw them in household waste. Contact your local pharmacy for proper disposal guidance.

Each film-coated tablet of Skudexa contains two active pharmaceutical ingredients:

• Dexketoprofen trometamol — equivalent to 25mg of dexketoprofen, a propionic acid-derived NSAID with analgesic and anti-inflammatory properties.
• Tramadol hydrochloride — 75mg, a centrally acting opioid analgesic that works on the central nervous system to help modulate pain signals.

These two active substances are combined in a single tablet to provide a dual-mechanism approach to pain management. The tablet also contains a number of inactive excipients (non-active ingredients) that help form and coat the tablet. Refer to the full patient information leaflet (PIL) included in your pack for the complete list of excipients.

• Allergy or hypersensitivity to dexketoprofen, tramadol, other NSAIDs (such as ibuprofen or aspirin), or any of the tablet's excipients
• History of asthma, bronchospasm, or allergic reactions triggered by aspirin or other NSAIDs
• Active peptic ulcer disease, gastrointestinal bleeding, or a history of recurrent GI ulceration
• Severe renal impairment (creatinine clearance below 30 mL/min)
• Severe hepatic impairment or active liver disease
• Severe heart failure or uncontrolled cardiovascular conditions
• Epilepsy or seizure disorders not adequately controlled by treatment
• Acute alcohol intoxication or concurrent use of alcohol, hypnotics, opioids, or psychotropic substances
• Use of monoamine oxidase inhibitors (MAOIs) — concurrent use or within 14 days of stopping MAOIs
• Pregnancy (especially from 20 weeks gestation onwards) and breastfeeding
• Children and adolescents under 18 years of age
• Patients with a known risk of opioid abuse or dependence
• Post-operative pain management in patients who have undergone coronary artery bypass graft (CABG) surgery

Drug Interactions

• Other NSAIDs or aspirin – Increased risk of gastrointestinal bleeding and ulceration.
• Anticoagulants (e.g., warfarin) – May enhance blood-thinning effects and increase bleeding risk.
• Antidepressants (SSRIs, SNRIs, tricyclics) and MAO inhibitors (MAOIs) – Increased risk of serotonin syndrome and serious adverse effects.
• Opioid analgesics, sedatives, hypnotics, or anxiolytics (e.g., benzodiazepines) – Increased risk of excessive sedation, CNS depression, and respiratory depression.
• Methotrexate or lithium – NSAIDs may increase blood levels, raising the risk of toxicity.
• Antihypertensive medicines (e.g., ACE inhibitors, beta-blockers, diuretics) – NSAIDs may reduce their effectiveness and affect kidney function.

Food & Lifestyle Interactions

• Alcohol – Avoid alcohol while taking Skudexa, as it significantly increases the risk of gastrointestinal bleeding, excessive sedation, and CNS depression.
• Grapefruit juice – May interfere with tramadol metabolism and is best avoided during treatment.

1. Do I need a prescription to buy Skudexa 75mg/25mg Film-Coated Tablets in Singapore?
Yes, Skudexa 75mg/25mg Film-Coated Tablets is a prescription-only medicine (POM) in Singapore. This means you will need a valid prescription from a registered doctor before purchasing. At our online pharmacy, we take prescription requirements seriously to ensure your safety and comply with Singapore pharmaceutical regulations. Please have your prescription ready when placing your order.

2. Can I purchase Skudexa 75mg/25mg Film-Coated Tablets online in Singapore?
Yes, you can order Skudexa 75mg/25mg Film-Coated Tablets through our licensed online pharmacy, which serves customers across Singapore. We are committed to providing genuine, registered medicines sourced through authorised pharmaceutical channels. Simply upload your valid prescription during the checkout process and our team will verify it before processing your order.

3. How do I submit my prescription when ordering online?
It's easy! During the ordering process, you can upload a clear photo or scanned copy of your doctor's prescription directly on our website. Our in-house pharmacist will review and verify the prescription before your order is confirmed and dispatched. If you have any questions about submitting your prescription, our customer support team is happy to assist you.

4. Is the Skudexa sold on your website authentic and registered?
Absolutely. All medicines sold through our online pharmacy, including Skudexa 75mg/25mg Film-Coated Tablets, are sourced from authorised distributors and registered with the Health Sciences Authority (HSA) of Singapore. We do not sell counterfeit or unregistered products. Your health and safety is our top priority, and we maintain strict quality assurance standards across all our pharmaceutical products.

5. How long does delivery take for orders within Singapore?
We offer delivery across Singapore. Delivery times typically range from 5 to 7 working days, depending on your location. Orders are processed promptly once your prescription has been verified. You will receive a tracking number via email or SMS once your order has been dispatched.

6. Is my personal and medical information kept confidential when I order online?
Yes, absolutely. We take your privacy very seriously. All personal data and prescription information submitted through our platform are handled in strict accordance with Singapore's Personal Data Protection Act (PDPA). Your information is never shared with third parties without your consent, and our website uses secure encryption technology to protect your data at all times.

7. What should I do if my Skudexa tablets arrive damaged or appear tampered with?
If your order arrives with damaged packaging, broken seals, or anything that looks unusual or suspicious, please do not take the medicine. Contact our customer service team immediately with photos of the product and packaging. We will arrange for a replacement or refund in accordance with our returns and quality assurance policy. Your safety always comes first.

8. Can I get a refund or return Skudexa if I no longer need it?
Due to the nature of prescription medicines and strict pharmaceutical regulations in Singapore, we are generally unable to accept returns on dispensed prescription medicines for safety and hygiene reasons. However, if there is a quality issue, a dispensing error, or the product was damaged upon arrival, please contact us and we will work to resolve the matter promptly and fairly.

9. How will my Skudexa order be packaged for delivery?
All prescription medicines, including Skudexa, are packaged discreetly and securely to protect the integrity of the product during transit. We use appropriate packaging materials to ensure the tablets are not exposed to excessive heat or physical damage during delivery. Your package will not display the name of the medicine on the outer packaging to maintain your privacy.